Methyl aminolevulinate
Metvixia (methyl aminolevulinate) is a small molecule pharmaceutical. Methyl aminolevulinate was first approved as Metvixia on 2004-07-27.
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Commercial
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Clinical Trials
80 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Actinic keratosis | D055623 | — | L57.0 | 5 | 4 | 12 | 9 | 16 | 44 |
| Keratosis | D007642 | — | — | 5 | 4 | 12 | 9 | 16 | 44 |
| Basal cell carcinoma | D002280 | — | — | 3 | 3 | 7 | 1 | 3 | 15 |
| Carcinoma | D002277 | — | C80.0 | 3 | 2 | 7 | 1 | 2 | 14 |
| Bowen's disease | D001913 | — | D00-D09 | 2 | — | 1 | 1 | 2 | 6 |
| Cheilitis | D002613 | HP_0100825 | K13.0 | 1 | — | — | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Basal cell neoplasms | D018295 | — | — | 2 | 3 | 6 | — | 2 | 11 |
| Skin diseases | D012871 | — | L00-L99 | 2 | — | 1 | — | 1 | 4 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | 1 | — | 2 | 4 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 1 | 1 | — | — | 3 |
| Skin aging | D015595 | EFO_0005422 | — | — | 1 | 1 | — | 1 | 3 |
| Precancerous conditions | D011230 | — | — | — | — | 1 | — | — | 1 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
| Squamous cell neoplasms | D018307 | — | — | — | — | 1 | — | — | 1 |
| Warts | D014860 | — | B07 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 3 | — | — | 1 | 4 |
| Photochemotherapy | D010778 | — | — | 1 | 2 | — | — | — | 2 |
| Phototoxic dermatitis | D017484 | — | — | 1 | 1 | — | — | — | 1 |
| Uterine cervical dysplasia | D002578 | EFO_1000910 | N87 | 1 | 1 | — | — | — | 1 |
| Facies | D019066 | — | — | — | 1 | — | — | — | 1 |
| Cutaneous leishmaniasis | D016773 | — | B55.1 | — | 1 | — | — | — | 1 |
| Leishmaniasis | D007896 | EFO_0005044 | B55 | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | — | — | — | 1 |
| Vulvar neoplasms | D014846 | — | C51 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | 1 | — | — | — | 1 | 2 |
| Wound infection | D014946 | — | — | 1 | — | — | — | 1 | 2 |
| Surgical wound infection | D013530 | — | — | 1 | — | — | — | 1 | 2 |
| Prostheses and implants | D019736 | — | — | 1 | — | — | — | 1 | 2 |
| Prosthesis-related infections | D016459 | EFO_1001406 | — | 1 | — | — | — | 1 | 2 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leg ulcer | D007871 | — | — | — | — | — | — | 1 | 1 |
| Rosacea | D012393 | — | L71 | — | — | — | — | 1 | 1 |
| Extramammary paget disease | D010145 | — | — | — | — | — | — | 1 | 1 |
| Mammary paget's disease | D010144 | — | C50 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Methyl aminolevulinate |
| INN | — |
| Description | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumulation of protoporphyrin IX in the skin lesions to which the cream has been applied. Subsequent illumination with red light results in the generation of toxic singlet oxygen that destroys cell membranes and thereby kills the tumour cells. It has a role as an antineoplastic agent, a photosensitizing agent, a prodrug and a dermatologic drug. It is functionally related to a 5-aminolevulinic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)CCC(=O)CN |
Identifiers
| PDB | — |
| CAS-ID | 33320-16-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1096562 |
| ChEBI ID | 724125 |
| PubChem CID | 157922 |
| DrugBank | DB00992 |
| UNII ID | — |
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Safety
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92 adverse events reported
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